Notizia
Data notizia: Tue, 16/07/2024 - 12:00
... functions to grow faster and survive adverse conditions,
for instance by increasing the production of specific proteins. research could ... rna-based therapies".
the findings pave the way for a deeper understanding of the molecular mechanisms underlying rna therapies, which is crucial
for the development of more effective and less invasive treatments for numerous disease conditions.
the research was supported by airc and ... (pnrr) allocated to the project entitled 'national centre for gene therapy and drugs based on rna technology'.
references:
...
further information
francesca cutruzzola department of biochemical sciences "a. rossi ... rna. the research results supported by the airc foundation for cancer research have been published in the journal molecular cell. if the ... are confirmed in further studies, they may offer new hope for applying rna therapies in the fight against cancer
rna therapies: ...
Notizia
Data notizia: Thu, 01/10/2020 - 13:45
... to study the evolutionary dynamics of the lake since its formation, researchers have compared environmental and climatic data to the ... alessia masi of sapienza showed that shortly
after the formation of the lake, and within a few thousand years, the first evolutionary events that quickly led to the formation of new species took place
. many of these species had a short life ... how
"new" and small lakes offer great opportunities for speciation
.
on the other hand, these ecosystems are also
... soil and lake level. there has been a drastic decline in the rate of speciation and extinction as a result of the increase in ... of long-lived species, is actually rich in elements useful for understanding the biological evolutionary dynamics. that is why the outcomes of our study could have a strong
impact also for future research on biodiversity
."
references:
deep drilling reveals massive shifts in evolutionary dynamics after formation of ancient ecosystem
wilke t., hauffe t., jovanovska e., ...
Notizia
Data notizia: Wed, 03/02/2021 - 11:00
... in the chemokine prokineticin 2 (pk2) has been demonstrated for the first time in the serum of patients with parkinson's disease. the ... early biomarker of parkinson's disease and a drug target for the development of potentially useful therapies in the disease.
the next ...
doi: https://doi.org/10.1002/mds.28458
further information
roberta lattanzi department of physiology and pharmacology ... council and the university of rome tor vergata, has shown for the first time an increase in the chemokine prokineticin 2 (pk2) in the ... a biomarker and as a drug target to develop useful therapies for parkinson's disease
parkinson's disease: new potential biomarker ...
Pagina
funding institutional
is an online tool promoted by elsevier that allows professors, researchers and phd students to identify new international funding opportunities compatible with their career and research interests. developed for researchers and, more generally, for anyone interested in researching and selecting external competitive calls, ... landscape of international funding, offering detailed information on funding calls, funding bodies and grants awarded, using a database ... list of numerous international funding opportunities for researchers; list of funding opportunities, useful for planning your own fundraising strategies for research; email notifications of new funding opportunities; the ability to ...
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... the participation of professors, researchers and phd students in programmes and funding calls published by public and private bodies ... funding opportunities organisation of training and information days scouting of opportunities and pre-feasibility assessment of project ideas support for the presentation and drafting of project proposals; support to ... the main financial instrument promoted by the european union for the period 2021-2027, which is divided into various and multiple sections national and local calls for proposals , including the prin call, promoted by the ministry of universities and research for the funding of research projects of national interest national and international calls for tenders to promote widespread dissemination of information on calls for proposals and funding opportunities for research, ...
Notizia
Data notizia: Fri, 03/02/2023 - 14:00
... ideas and present the research that young female phd students, research fellows and researchers from different fields are carrying ...
Notizia
Data notizia: Thu, 07/11/2019 - 13:00
... we all studied at school. in this geometry, two parallel lines will never meet and the sum of the internal angles of a triangle is ... cosmic background radiation.
these anisotropies, which formed billions of years ago, have practically crossed the entire universe, and ... of cosmic background radiation, revealing good compatibility for the hypothesis of the universe's flatness and confirming the predictions of ... of the
data obtained by the planck satellite
performed by an international team lead by alessandro melchiorri has significantly ... no longer valid. as on the surface of a sphere, two parallel lines will meet, and the inner angles of a triangle add up to more than 180 ... if we were to traverse a cosmological distance in a straight line and at the speed of light, we could return to our starting point. this has ...
if the universe is closed, this also poses a problem for the planck measurements and recent surveys
of galaxies such as boss. both of these measurements provided compatible values for the abundance of matter and the value of the hubble constant of a flat ...
Notizia
Data notizia: Fri, 31/01/2025 - 14:00
...
each of which defines a rhythmic category. a note, for example, may last as long as the previous one, or twice or three times as ... key role of these temporal structures in rhythm perception. for the first time, researchers have shown that
horses' gaits also share ... galloping,' says andrea ravignani. these studies continue a line of research in which our universities have joined forces to investigate
the rhythmic characteristics of animal and human ... between music, animal communication and locomotion reinforces the idea that locomotion and motor control may have played a crucial ... and that of other species,' concludes lia laffi, a phd student at the university of turin in collaboration with the fondazione zoom. ... gait and vocal rhythmicity share key features, with the former probably predating the latter. indeed, the ability to produce and ... rhythms may have been a fundamental pre-adaptation for the development of more complex vocal rhythms at a later evolutionary ...
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graphergia
- innovative pilot lines for sustainable graphene-based flexible and structural energy harvesting and ... - 2d materials-based devices and systems for energy storage and/or harvesting
sapienza's role in the project:
other beneficiary
scientific supervisor for sapienza:
tullio
scopigno
department:
physics
... structural sensors and (ii) next-generation electrodes for li-ion batteries. based on current trl 3-4 activities, the consortium explores novel ideas for 2d materials engineering and integration at trl 5 or higher, establishing versatile pilot-scale-based approaches for these two types of applications. configurations of teng-based e-textiles ... electrode" approach to fabricate next-generation electrodes for li-ion batteries aspiring to reach the technical/economic targets of the ... of the charge state of electrodes, which is essential for improving li+ cell lifetimes, as well as monitoring cell ageing by ...
Pagina
for the last forty years, sapienza's archeological missions have represented one of the most important research perspectives for our university. the archaeological missions initially consisted of a ... (24), involving numerous professors, researchers and students. the excavations cover a wide geographical area (italy, the near and ... academic staff's research, sapienza annually promotes a call for "grandi scavi" (large excavations), which aims to support archaeological ... academic senate approved the 2022 "large excavations" call for proposals with a total budget of EU 900,000.00. click on the italian version of this page for more details and information.
sapienza's archaeological missions - call ...
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... the project:
affiliated entity
scientific supervisor for sapienza:
gianfranco caruso
department:
astronautical, electrical ... multicultural and competitive environments. enen# stands for the largest and most integrative nuclear education and training (e&t) efforts up to date. attraction of excellent new talents followed by outstanding ... activities are the overarching objectives. an excellent workforce should remain the basic enabler of safe long-term operation of existing ... into the eu supply and demand of nuclear human resources for power and non-power applications will be developed. this will include ... through dedicated career-related events and competitions for high school pupils and teachers, students (bsc, msc, phd), postdocs and lifelong learners. a strong mobility ... to the needs; the organization of events for bsc/msc/phd students; the revision of existing eu strategy for e&t in nuclear. /*--> */ ...
Notizia
Data notizia: Sun, 13/11/2022 - 18:30
... rector antonella polimeni expresses her deep sorrow for the untimely death of maurizio falcone, professor of numerical analysis at ... science, fluid dynamics and image processing. colleagues and students appreciated his intelligence and passion. the funeral will take place ...
Notizia
Data notizia: Mon, 12/10/2020 - 13:00
... to present the rome trial,
a unique study
both for its interdisciplinary approach and the use of futuristic techniques of ... to participate, you must be accredited. please note that for safety reasons only a limited number of seats will be available. those who ... the link at tesorieuronet@gmail.com or stampa@uniroma1.it . for further information and details, please visit the italian version of this article.
on ... to present the rome trial, a unique study in the world, both for its interdisciplinary approach and the use of futuristic techniques of ...
Notizia
Data notizia: Fri, 26/02/2021 - 12:00
... sapienza research projects
as winners of the 2020 call for proposals on rare genetic diseases. the projects are
among the seven ... million euros and among the 45 awarded at the national level for about 10 million euros. the research project coordinated by
paola bezzi ... deficits typical of
22q11 syndrome
, a congenital malformation disorder, in order to identify new potential therapeutic targets.
... on identifying new functions of the nbs1 gene, responsible for
nijmegen syndrome,
a rare genetic disease characterised by ... five hundred eighteen researchers throughout italy applied for funding under the 2020 call for proposals promoted by the telethon foundation, of which 139 were selected ... are being studied in the projects:
these include various forms of muscular atrophy and dystrophy, eye diseases such as schnyder's lens ... as huntington's disease, angelman's syndrome and various forms of epilepsy.
the telethon foundation has selected two research ...
Notizia
Data notizia: Tue, 27/06/2023 - 12:00
... from the ultra-rare
aadc deficiency
hit the headlines after his parents wrote a heartfelt letter to the italian government asking for help so that their son could receive the urgently needed therapy that other ... process in italy; that is why the family had to wait for a year, an enormous amount of time when facing a degenerative disease. the ... in rome
, the only italian centre equipped and authorised for the delicate procedure involving the infusion of the therapy directly into ... hospital and sapienza. the treatment, approved by the ema for aadc deficiency, was infused directly into the brain in a neurosurgical ... child with very rare disease receives gene therapy never before used in italy ...
Notizia
Data notizia: Fri, 21/07/2023 - 12:00
... sadori was elected new president of the international union for quaternary research,
at the end of
inqua 2023,
the most important ... over six days. it is an important recognition awarded
for the first time to an italian
scholar in inqua's 95-year history. the ... and human impact on vegetation. her expertise and passion for reconstructing our planet's recent history are reflected in her work, which ... of the work that our quaternary scientists have been doing for over a hundred years. italy has always played a leading role in this field ... sadori was elected president of the international union for quaternary research (inqua) at the end of inqua 2023, their 21st world ...
Notizia
Data notizia: Mon, 06/06/2022 - 14:00
... by several mutations in the cftr gene
, which codes for a membrane protein with a chlorine channel function, called the cystic ...
has revealed a possible
alternative therapy
for cystic fibrosis involving two drugs already in clinical use for other diseases,
a protein inhibitor (camostat), a coenzyme (s-adenosyl ... of the university of foggia. 'although precision therapy for cystic fibrosis acting on the cftr protein is now possible (even if only for certain mutations),
the proposed therapeutic approach, which instead acts on the enac channel
, could be performed,' says marco lucarelli, 'at the same time as precision therapy in order ... proposed in this study - two drugs already in clinical use for other diseases and a food substance - are more likely to be used in the ... marco lucarelli, '
opens the way to new possibilities for treating this disease, in which epigenetics itself could be considered a ...
Notizia
Data notizia: Wed, 30/08/2023 - 14:00
... and rome),
a hydrographic drone,
specially configured for work at extreme latitudes,
was used for the first time
to obtain very high-resolution 2d and 3d bathymetry of
... to the expected environmental conditions in the region for the near future. "the drone used was designed and adapted precisely for this purpose: small, lightweight and easily transportable - says david ... lakes at the foot of glaciers that had never been mapped before. the results obtained and volumetric calculations of the lakes will, then, be correlated with ecological data to obtain unique information on these delicate aquatic ecosystems." "although the use of drones is ... provided and configured by seafloor system inc. for the portable hydrographic drone and the italian company microgeo for the global navigation satellite system (gnss) antenna. data acquired ...
Notizia
Data notizia: Wed, 04/04/2018 - 15:00
... side effects, such as permanent cognitive impairments. for this reason, the discovery of
alternative and innovative treatments is ... a new molecular mechanism, whose alteration is responsible for
development of medulloblastoma.
the results of the work, which represents a nodal point for the development of new therapeutic strategies, are published in the ... in several cancers, thus representing an important target for more effective and therefore less toxic anticancer therapies". researchers from sapienza university and ... this process induces gli3 to act as a
red light
for tumor growth, enhancing its ability to suppress cell proliferation. to ... to develop novel and more effective therapeutic approaches for the treatment of this malignant brain tumor".
references:
... 976 (2018) doi:10.1038/s41467-018-03339-0
further information
lucia di marcotullio - department of molecular medicine t (+39) ...
Notizia
Data notizia: Mon, 23/09/2024 - 15:00
... on september 15 at the esmo congress (european society for medical oncology), by researchers of sapienza university of rome, showed ... the winning approach to cancer treatment today is to search for the genetic mutations present in the individual patient's malignancy, which are increasingly decisive for choosing the most suitable therapy with the highest probability of success. ... sapienza university at the esmo congress (european society for medical oncology), was conducted on over 1,700 patients involving 40 ...
Notizia
Data notizia: Fri, 02/08/2019 - 12:00
... composed of nucleic acids that transfers the genetic information contained in dna to produce the proteins that ensure the correct ... biotechnology, in collaboration with the barcelona centre for genomic regulation and the university of frankfurt has revealed for the first time that, under certain circumstances, messenger rna could act as a molecular chaperone,
blocking the formation of protein aggregates that are potentially toxic to our organisms
... predictions, the researchers experimentally demonstrated for the first time that, under conditions of stress, messenger rna hsp70 ... the removal of the protein aggregates that are responsible for serious neuro-degenerative diseases such as alzheimer's and amyotrophic ... that directly associates rna to its protein products
for all genes that are highly active in cellular processes." the results of the ... 10, 3246. doi: 10.1038/s41467-019-10923-5
further information
gian gaetano tartaglia "charles darwin" department of biology and ...
Notizia
Data notizia: Fri, 12/11/2021 - 12:45
... only to reveal themselves under tissue stress, and are therefore defined as 'cryptic'. these can be revealed, for example, during the apoptotic process of t lymphocytes, i.e. when these ... multiple sclerosis society (aism); various italian and foreign organisations and universities, such as the carlo besta neurological institute in milan, la jolla institute for immunology in san diego (usa), federico ii university in naples, cnr institute for endocrinology and oncology in naples, irccs santa lucia and pasteur ... showed that after disease induction,
t cells specific for cryptic antigens accumulate in the central nervous system
and exhibit an effector phenotype, i.e. they can perform their functions without the need for co-stimulatory signals. these cells also exist in healthy animals but are ...
Notizia
Data notizia: Fri, 02/02/2024 - 09:00
the use of electronic devices for smoking tobacco is increasing rapidly, with many young people taking up ... to market analysts. tobacco smoking is a known risk factor for several diseases, while the health effects of e-cigarettes, defined as a "modified risk product", are still ongoing. therefore,
awareness of the consequences of tobacco use through heat-not-burn ... released by the tobacco companies themselves. hence the need for observational studies aimed at understanding whether the health effects, ... council, the university of turin, the italian institute for genomic medicine in candiolo, turin, and irccs neuromed, observed changes ... of healthy, young smokers recruited between 2019 and 2020 for the sur-vapes chronic study, conducted by sapienza. the sample comprised of ... and smokers of heated tobacco cigarettes. the data show for the first time that even heat-not-burn cigarettes, which are considered ... in a similar way to traditional combustion cigarettes. therefore, the consequences of the two types of smoking on circulating micrornas are ...
Notizia
Data notizia: Mon, 18/12/2023 - 12:00
... brain is particularly energy-efficient because it handles information by storing it in the same elements that process it. in contrast, for computers, the way calculations are performed currently requires storing and processing information in different parts of the computer, making the process not very ... by components of the human brain, may represent a major step forward in artificial intelligence applications.
a study coordinated by ... control the passage of ions in the brain and are essential for the propagation and processing of electrical signals in the nervous system. ...
- a nanopore - that, by exploiting hydrophobicity and the formation of nanobubbles,
can reproduce the electrical behaviour of natural ... this new study develops a quantitative theory for this phenomenon,
showing, for the first time, that under certain ...
Notizia
Data notizia: Fri, 31/01/2020 - 14:00
...
white shark
has lived in the mediterranean sea for centuries?
main character of numerous tales and famous films, the king ... the last few years, has encouraged the international union for the conservation of nature (iucn) to include it among the species currently ... study, in partnership with sapienza university of rome, stanford university, virginia tech university, the institute for biological resources and marine biotechnology, the national research ... stazione zoologica anton dohrn, naples, and the institute for environmental protection and research (ispra), rome,
has estimated, for the very first time, a pattern in the population trend of the king of ...
by an increasing phase followed by a sharp decline
since the second half of the twentieth century. "the decrease - says ... - was not homogenous throughout the mediterranean basin. for instance, in central mediterranean sectors, a 52% decrease was observed, ...