NETWORK ONCOLOGY AND PRECISION MEDICINE

ID : 
30887
Course type : 
Dottorato
Positions : 
3
Grant numbers : 
1
Number of scholarships financed by institutions : 
0
Number of scholarships financed by consortiums : 
1
Educational goals

Aims of PhD program “Network Oncology and Precision Medicine” The PhD Program in "Network Oncology and Precision Medicine" offers a training course that fits into the new vision of modern oncology based on the personalization of treatments in order to give the best therapeutic option to each individual patient. Nowadays, even more than before, when the multiplicity of treatments and their possible sequences of administration (chemo-radio, target therapy, immunotherapy) makes it possible to modulate the therapeutic path during the progression of the disease. The PhD is addressed to students coming from master's degree programs both in the medical-biological and scientific-technological areas, motivated to enrich their skills with new knowledge of molecular oncology and computational analysis. The main goal of the PhD in "Network Oncology and Precision Medicine" is to train a new kind of researcher in the medical field, an innovative and crucial figure for his role, characterized by the convergence of different skills in the context of the multidisciplinary team, that must redefine oncological problems in order to classify, diagnose, plan treatments and identify prevention paths within the oncological medicine network. In oncology, advanced technologies allow us today to be able to acquire molecular and biological data for each individual patient in a very short time and at low costs. To date, the clinical impact of this bio-molecular information is still limited as there is a lack of technological and IT tools for their effective integration with the data most classically used in clinical practice. Consequently, in order to achieve an optimal personalized cancer therapy, the clinical data of each patient must be integrated with information derived from molecular data, with the availability of target drugs, with data from clinical trials and compared with experimental and basic research. The complexity and dynamic nature of the different types of data available for each oncology patient require new architectures, algorithms and networking strategies to be accessible to the oncologist that is taking care of the patient and to pharma industries, for the refinement and upgrading of therapeutic options. The shifting towards the “network medicine” method in oncology may represent a true improvement in the clinical management of oncological patients, optimizing early-stage diagnosis/screening programmes and therapeutic approach, with a likely reduction in expenses related to oncology patients, as postulated by precision medicine. The PhD program in “Network Oncology and Precision Medicine” aims at an educational path built on an interdisciplinary approach to the research topics with the focus on the identification of new biomarkers for precision medicine in oncology and on the development of new-generation models and algorithms based on “network medicine”, The educational path of the proposed PhD program is strongly supported by the highly collaborative environment of collaborations both at Sapienza University and with external research institutes, national and international. Academic disciplines included are general pathology, medical oncology, informatics, bio-engineering, processing systems, medical statistics, pharmacology, endocrinology, laboratory medicine, medical genetics and Pathological Anatomy. All the different expertises/skills are represented by the academic fields of the board members of the PhD program. 1) Regarding expertise on molecular and cellular pathology, microbiology and applied medical sciences and laboratory medicine, the following disciplines are included: MED/04 and MED/05 General Pathology and Clinical Pathology (Prof. Nuti, Ferretti, Rughetti, Galuzzi, Besharat, Zizzari) The field covers scientific and teaching activities, as well as a medical practice for general pathology and physiopathology. Basic research fields are molecular medicine and cellular pathology with a focus on oncology, immunology, immunopathology, genetic and epigenetic pathology. Of note, general pathology will set the basis for the educational path of the PhD program, since these notions are crucial for the later studies of the cellular and molecular mechanisms of cancer. MED/07 - Microbiology and Clinical Microbiology (Prof. Vernocchi e Putignani) This academic field deals with scientific and teaching activities on the mechanisms of microbial pathogenicity, host-pathogen interactions and microbial biotechnologies. Topics include bacteriology, virology, parasitology and clinical and diagnostic aspects of viral and microbial analyses. Recently, the crucial role of the microbiome in the response to oncological treatments was highlighted. Therefore, these topics will be included in the PhD program in “Network Oncology and Precision Medicine”. MED/46 - Laboratory Medicine (Prof. Pierelli, Po, Napoletano) This academic field deals with scientific and teaching activities in laboratory medicine. Topics will deal with technologies in clinical biochemistry, pathological histology, cytology, cytopathology, ultrastructural pathology and applied genetics. The PhD program addresses these subjects since they are the tools for the generation of different types of clinical data. MED/50 - Applied medical sciences (Prof. Malapelle, Pelliccia) This academic field deals with scientific and teaching activities, as well as clinical practice regarding technologies for Diagnostic imaging and radiotherapy, critical care and emergency, hygiene and Environmental protection. Topics will include diagnostic methodologies, oncology treatments and the study of disease biomarkers. BIO/10 – Biochemistry (Prof. Clausen, Prof.Reis) This academic sector studies the properties and functions of biomolecules with particular reference to proteins and nucleic acids. The analysis of molecular and regulatory mechanisms of biotransformations, enzymatic catalysis, signal transduction, intra and intercellular communications is of interest. Particular attention is paid to the study of the biochemical mechanisms of cell functions with identification, characterization and analysis of biomolecules, molecular structural biology, biocrystallography, biophysics, computational biochemistry and bioinformatics. The inclusion of this sector in the PhD program offers students the tools of innovative techniques of biochemical and biotenological applications in the medical field and the biochemical basis of disease states. BIO/11 – Molecular Biology (Prof. Rajewsky) This academic field deals with the study of biological functions and post-transcriptional regulation of molecules involved in pathologies, the evolutive and biochemical properties of nucleic acids, interactions between nucleic acids and proteins, and protein-protein interaction. A specific focus will be the study of macromolecules involved in conservation, repair, duplication, transcription and translation of the information stored in the DNA, and macromolecules involved in the control of gene expression, proliferation, differentiation and malignant transformation. This scientific field offers innovative techniques in genetic engineering, bio-crystallography and bioinformatic tools for the biochemical characterization of biological macromolecules to PhD students. 2) Regarding expertise related to general and specialist medical oncology, diagnostic imaging and pathological anatomy, the following disciplines are included: MED/06 - Medical oncology (Prof.Marchetti, Prof. Botticelli, Prof. Mezi, Prof. Ascierto, Prof. Santini, Prof. Curigliano, Prof. Pfister) The academic field includes scientific, educational-training and clinical practise in medical oncology. In this medical discipline, advanced technologies allow for the collection of numerous molecular and clinical data for each patient. The inclusion of this academic field in the course of the PhD in Network Oncology and Precision Medicine offers students training courses for the diagnosis of solid tumors and choice of anticancer therapies. Particular attention is paid to the development of innovative approaches based on a thorough understanding of the critical relationships between cancer cells and the microenvironment with particular attention to the tumor immune environment. MED/18 – General Surgery (Prof. Marco Biffoni) This academic field is interested in scientific and didactic-training activities, as well as in the assistance activity appropriate to it in the field of surgery. Surgery in oncology, both traditional and minimally invasive, are specific areas of expertise. The inclusion of this sector in the training course of the PhD offers students an in-depth study of aspects of the surgical approach in cancer therapy. M-EDF/02 Methods and Didactics of Sports Activities (Prof. Romanelli) The sector deals with the development of theories, techniques and methods for training and for the practice of different sports activities. Physical activity acts on essential mechanisms of the body such as metabolism, inflammation and the immune system and is therefore also important in cancer patients. Specifically, during the course of the PhD in Network Oncology and Precision Medicine, this discipline will be addressed to improve the quality of care and assistance to the patient. MED/08 – Pathological Anatomy (Proff. D’Amati, Antonelli, Loda) This academic field is interested in scientific and didactic-training activities, as well as diagnostic assistance in the field of anatomy and pathological histology with specific skills in cyto-histopathology, histochemistry, immunohistochemistry, anatomical-pathological ultrastructural and molecular diagnostics and in anatomy and pathological specialist histology oncology. In this context, during the PhD useful information will be introduced to assist in the determination of personalized treatments in cancer patients. 3) Regarding expertise related to Information Processing Systems and Statistics, the following disciplines are included: ING-INF/05 - Information Processing Systems (Proff. Armerini e Lenzerini) This academic field is interested in scientific disciplines related to the design and implementation of information processing systems, as well as their management and use in various application contexts with engineering methods and techniques. Theoretical foundations, methods and technically valid technologies fall within this sphere. These foundations, methods and technologies cover all aspects relating to a computer system, from hardware to software, from operating systems to computer networks, from databases to information systems, from programming languages. The inclusion of this academic field in the course of the PhD in Network Oncology and Precision Medicine is necessary in oncological medical research for the optimal processing and integration of molecular, clinical and other data (e.g. clinical trials) and will assist in the definition of the best clinical-diagnostic and therapeutic approach. MED/01 - Medical Statistics (Prof. Preissner) This academic field is interested in scientific and educational-training activities in the field of statistical and statistical-epidemiological methodologies applied to the biomedical and clinical fields, anthropometry and biometrics as well as to health planning and the organization and management of health services. The inclusion of this academic field in the training course of the PhD in Network Oncology and Precision Medicine is fundamental for the design, analysis and evaluation of experimental and observational studies in oncology. In addition, this discipline provides the knowledge and methodologies for the identification of tumor disease biomarkers. 4) Regarding expertise related to medical Pharmacology, the following disciplines are included: BIO/14 - Pharmacology (Prof. Pirmohamed, Prof.Schmidt) This academic field aims to train, on a didactic and scientific level, specific professional skills for the knowledge and study of drugs on an experimental and clinical level. It deals with studying the mechanism of action of drugs, the suitable methodologies for the evaluation of the effects of drugs, drug-toxicokinetics, the determination and control of posologies and the detection and evaluation of adverse reactions and their treatment; it also assesses the risk / benefit and cost / benefit ratio of drug interventions. The sector includes immunopharmacology as specific aspects. The inclusion of this academic field in the PhD in Network Oncology and Precision Medicine is necessary for the identification of therapeutic strategies designed specifically taking into consideration the needs of each oncological disease. And finally, it is a fundamental discipline, always in regards to personalized medicine, in order to optimize pharmacological efficacy and minimize its toxicity. The PhD Faculty Board is characterized by the participation of Professors from different academic Scientific Disciplinary Sectors to ensure the convergence of medical-biological and scientific-technological knowledge. Only the fusion of this knowledge can provide an advantage in the face of the challenge of precision medicine in oncology. In this context, the main aim of the PhD Program to create innovative programs that lead to better precision medicine is to take advantage of the research collaborations already underway between the different members of the faculty board. In addition, the professors of the PhD will create and promote collaborations within the PhD program through the implementation of interdisciplinary and international research projects with research centers of excellence in the field of various disciplines. Italian research and hospital institutions participate in the PhD program, such as the Istituto Superiore di Sanità (Dr. Mauro Biffoni), the Sant'Orsola Malpighi hospital (Dr. Lidia Strigari) and the IRCCS Bambino Gesù Pediatric Hospital (Dr. E Miele, A. Mastronuzzi, L. Putignani, P. Vernocchi) who, with their staff and structures, enrich and integrate the clinical-scientific skills offered by the teaching body, with particular regard to pharmacology (SSD/MED14), statistics (SSD/MED/01), oncology (SSD/MED06) and microbiology (SSD/MED07). The interdisciplinary research projects will be developed by the PhD faculty board. The projects will concern the network medicine for oncology and will be supervised by Harvard Medical School (with which Sapienza has a framework agreement) where Prof. Loscalzo was the first in the world to develop and apply the network medicine, in particular Prof Elisabeth Battinelli joined the PhD in Network Oncology and Precision Medicine. Below is a description of the Departments of the "Sapienza" University and of the external academic and research centers (Italian and foreign) that are involved in the PhD. DEPARTMENTS OF THE "SAPIENZA" UNIVERSITY Department of Experimental Medicine, Head of Department - Prof. Lenzi (n=8) Proff. M. Nuti, A. Rughetti, E. Ferretti, L. Pierelli, C. Napoletano, F. Romanelli, Z.M. Besharat, I.G. Zizzari) Composition: The Department brings together 83 Professors of the Faculty of Medicine and Dentistry (22 POs, 29 PAs and 32 Researchers) and 21 units of technical-administrative staff belonging to different SSDs who conduct teaching, multidisciplinary and translational research and clinical assistance. The department represents the "Sapienza" University in the "LifeTime" European Consortium. LifeTime is a new pan-European consortium established in 2018 by more than 90 biomedical research centers of excellence supported by 70 industries, which aims to revolutionize "healthcare" by mapping, highlighting and specifically targeting pathological cells (https: //lifetime-fetflagship.eu/). The department shares the objectives of the LifeTime Consortium and for this reason has involved the Founder and coordinator of the Consortium Prof Nikolaus Rajewsky to be part of the external teaching staff of the proposed PhD Program. Prof. Nikolaus Rajewsky is an internationally renowned scientist and for this reason he received the PhD ad Honoris causa in Human Biology and Medical Genetics in 2014 from the Sapienza University of Rome (https://www.uniroma1.it/en/notizia / doctorate-honoris -causa-nikiolaus-rajewsky; https://www.mdc-berlin.de/news/archive/2014/20140611- rome_s_sapienza_university_awards
honorary). The teaching activity is diversified and carried out within the Degree Courses in Medicine and Surgery, in the Degree Courses for Health Professions, in various post-graduate training courses, two Specialization Schools in Endocrinology and Metabolic Diseases and Science of the Nutrition and in PhD courses and I and II level Masters. Didactic Facilities: The Department of Experimental Medicine has at its disposal - 4 classrooms, which can be booked for educational use: Aula Bignami, Aula Vernoni, Aula Caramia, Aula Conti - 1 meeting room - 1 Interdepartmental Library between the Departments of Experimental Medicine and Molecular Medicine headquarters of General Pathology with a large reading room. The Library adheres to the Sapienza Library System (SBS) and its activities are coordinated by an interdepartmental technical-scientific committee. It has a significant bibliographic heritage that has grown richer over the years. The Library annually subscribes online ("campus" format accessible to all Sapienza users) or printed to a group of biomedical journals and participates in the purchase of online packages together with the other Libraries of the Biomedical Area. The Library has a Document Delivery service (by sending a specific request to the following email address: bib.stomed@uniroma1.it) with which it is possible to request articles not owned directly by the Library from the staff. Research activity: The research activity focuses on some particularly relevant areas such as molecular and clinical onco-immunology, oncogenomics, experimental, molecular and viral oncology, tumor pathophysiology, systems biology, molecular, cellular and clinical endocrinology. Available tools and laboratories: PhD students will have access to laboratories which include benches for experimental work and workstations with desks. There are laboratory computers with Sapienza internet access, which therefore includes access to the Scientific Resources included in the University subscriptions, and internet access for private computers, that will allow students to access the internet through Sapienza. The molecular biology and conventional biochemistry laboratories are equipped with refrigerators, freezers, ultra-freezers, extraction hoods for chemical use. Cell culture rooms equipped with laminar flow hoods, incubators, and centrifuges. There are also tools dedicated to scientific research such as: inverted phase contrast and fluorescence microscope, thermal cyclers, nano spectrophotometer, cryopreservation system with liquid nitrogen, instruments for flow cytometry analysis, LSM 5 Exciter time-lapse live videomicroscopy, Electron microscope scanning, automatic nucleic acid extractor (Maxwell, Promega) Nucleic acid sequencer Nanostring N counter Sprint Profiler (Diatech Lab Line), Digital PCR Biorad, Flow Cytometer, LC-MS system with HPLC pump and mass spectrometer. Diagnostic and clinical care takes place in the clinics and laboratories of tumor immunology and immunotherapy, oncogenomics, molecular pathophysiology, clinical pathology and genetic-metabolic diseases, endocrinology, metabolic diseases and the science of food and nutrition. Prof. Nuti, a member of the department, is involved in the Foundation for Personalized Medicine (https://fondazionefmp.it/) which is dedicated to defining a "specific" identity for each patient that leads to the best treatment. Department of Molecular and Clinical Medicine, Head of Department - Prof. Taurino, (n=2) Prof. P.Marchetti, A.Botticelli The Department of Clinical and Molecular Medicine is consisted by professors who belong to various scientific-disciplinary sectors relating to molecular and cellular medicine, diagnostics, clinical medicine and surgery, in order to: promote the advancement of knowledge on the etiopathogenetic mechanisms of cardiovascular, haematological, respiratory, endocrine, nephrological, urological, oncological and immune and hereditary diseases; develop research topics in the field of biomedicine and biotechnology aimed at identifying new diagnostic and therapeutic approaches for application in high-impact pathologies in the socio-health sector; experimenting with new theoretical and practical teaching activities for training in the biomedical and surgical sectors. Multidisciplinarity is the main characteristic of the department, a strong point for the development of interdisciplinary and translational themes. The research activity, aimed at satisfying the growing requests for a medicine of excellence and modern in its contents and applicability, is developed in an integrated way and strictly connected functionally to the clinical-assistance activities of the Sant'Andrea Hospital and to the educational activities of the University. Prof. P. Marchetti from the Department of Molecular and Clinical Medina is the founder of the Foundation for Personalized Medicine (https://fondazionefmp.it/) which is dedicated to defining for each patient a "specific" identity that leads to the best treatment. The Department offers 1 central library of the Faculty of Medicine and Psychology, which is located on the ground floor of the S. Andrea Hospital, 7 classrooms available to students and 1 computer room. Department of Surgical Sciences, Head of Department - Prof.D’Andrea, (n=1) Prof. Marco Biffoni The Department boasts a long and qualified surgical activity. The current departmental organization has allowed a better operational articulation, a more congruous structural distribution and a definitive functional destination of the diagnostic-therapeutic structural complexes in relation to the activities of the Divisions and Services. The department conducts numerous studies concerning: colorectal cancer, gastric cancer, surgical methods of pancreatic adenocarcinoma, minimally invasive and robotic surgery and laparoscopic surgery. Department of Molecular Medicine, Head of Department - Prof. Maroder, (n=1) Prof. A.Po The Department of Molecular Medicine includes 78 professors with interdisciplinary cultural and technological skills and with research activities aimed primarily at the integration of basic research and translational research with many lines of research that are carried out in the field of oncology. The Department of Molecular Medicine is one of the Departments of Excellence. On January 9, 2018, the list of the 180 University Departments of Excellence that were awarded the funding was published on the ANVUR institutional website, as communicated by the Commission appointed with Ministerial Decree no. 262 of 11 May 2017. The project presented by the Professors and Researchers of the Department was 12th for the CUN 06 "Medical Sciences" area. The Department provides 1 classroom for didactic activities, a Library with a large reading room (shared with the Department of Experimental Medicine), 1 meeting room, numerous Research Laboratories fully equipped with the latest generation equipment including: real time PCR Viia7 (Thermofisher), nano-spectrophotometer, Luminometer (Promega Glowmax); Chemidoc (Bio-Rad) for the acquisition of chemiluminescence and ultraviolet; BSL3 laboratory for generation and handling of third generation lentiviruses; IncuCyte® S3 Live-Cell Analysis System (Essen Bioscience), Animal house for the maintenance and rearing of mouse animal models, both in standard conditions and free from specific pathogens (SPF); IVIS Lumina in vivo imaging tool (Perkin Elmer). PhD students will have access to laboratories which include benches for experimental work and workstations with desks. Laboratory computers with internet access are available at Sapienza University. Department of Radiological, Oncological and Pathological Sciences, Head of Department - Prof. Giangaspero, (n=3) Proff. G. D’Amati, M. Antonelli, S. Mezi The Department of Radiological, Oncological and Pathological Sciences includes professors from various scientific-disciplinary sectors in order to promote and coordinate teaching, research and assistance activities in the field of multimodal oncology, the underlying physiopathological and biomolecular mechanisms of oncological diseases and technological innovation of diagnostic and therapeutic imaging. Particular attention is paid to translational research in the oncology field, also through contracts and agreements with public and private institutions and bodies. The Department benefits from funding from the Ministry of Education, University and Research, and other public bodies and administrations. The Department provides 6 classrooms for didactic activities located in 2 buildings that make up the Department (Pathological Anatomy Building and Central Radiology Building) and also a Library with a large reading room (Ghilarducci Library). Furthermore, the Department provides 4 fully equipped laboratories for histopathological, cytological and mutational investigations. Department of Clinical, Internal, Anesthetic and Cardiovascular Sciences, Head of Department - C.Gaudio, (n=1) Prof. F. Pelliccia The Department born in 2019 from the merger of 2 Departments: Internal Medicine and Medical Specialties with that of Cardiovascular, Respiratory, Nephrological, Anesthetic and Geriatric Sciences. Today it brings together over 100 scholars including professors and researchers belonging to different teaching and research areas and offers health and educational services of excellence in the various medical areas that make up the structure. The presence of specialists in different subjects includes highly specialized skills such as that of Prof. Francesco Pelliccia who specializes in the study of the cardiovascular system of cancer patients undergoing therapies. Department of Computer, Automatic and Management Engineering (DIAG), Head of Department - Prof. Catarci I.Armerini (n=1) The Department of Computer, Automatic and Management Engineering (DIAG) with its name intends to reflect the evolution of its teaching and research mission and its roots in engineering. Research groups of international level in the areas of information technology, systems engineering and management are part of this deparmtent. The primary objective of the DIAG is basic research, with particular emphasis on interdisciplinary research, on applications that stimulate basic research, and on technology transfer and the dissemination and exploitation of results. The DIAG collaborates with other universities, research institutes and companies in Italy and around the world. It receives research contracts worth around two million euros per year from national and European funding sources. Regarding training, the mission of the DIAG is the preparation of engineers with professional opportunities in industries, public administration and universities. The DIAG has 11 classrooms for teaching activities, 2 meeting rooms, 1 classroom with videoconferencing system, 7 visitor spaces, 3 teaching laboratories and 11 research laboratories specialized in the various areas of interest of the department. The department's library houses 11,000 scientific volumes and offers online access to around 900 publications. DIAG was among 180 departments of excellence in Italy and received 8.5 million euros from MIUR, destined to create an international center of excellence in IT security, using its experience in numerous research areas, investing in human resources, infrastructures and activities innovative teaching. DIAG has an active scientific collaboration with Prof. Joseph Loscalzo, who deals with Network medicine, as part of the framework agreement between Harvard University USA and Sapienza (https://www.uniroma1.it/it/notizia / harvard-e -wisdom-allies-in-medical-research) EXTERNAL ITALIAN ISTITUTIONS Higher Institute of Health (I.S.S.) Department of Oncology and Molecular Medicine Dr. Mauro Biffoni The Department of Oncology and Molecular Medicine (OMM) of the Istituto Superiore di Sanità (ISS) is well equipped for research in the field of cellular and molecular biology. Equipment for Reverse-Phase Protein Microarrays is available, including a robotic system and an automatic staining system with a laser scan. The laboratories archive and preserve formalin-fixed biological samples embedded in paraffin and frozen, perform histopathology analyzes and laser acquisitions. They also work with high-resolution confocal microscopy systems with the ability to produce images of live cells in time laps. Flow cytometry facilities are available for cell cycle analysis and the expression of surface markers, together with the sorting of cells for the isolation of specific cell sub-populations and mass cytometry. The laboratories also have a thermal cycler for Real-Time PCR capable of accommodating plates from 96 to 384 wells; a Microplate Reader capable of acquiring fluorescence, chemiluminescence and radioactive signals; high resolution gel; an Imager Blot for easy acquisition of chemiluminescence; gels and blots for UV fluorescence analysis and multiple tools for immunoassays. Light-tight cryostats, imaging chamber with low background noise and a complete gas anesthesia system that allows the acquisition of images directly from animals. Finally, it makes use of the presence of an individual ventilation system for the treatment of immunodeficient mice and protocols for in vivo experiments already approved by the competent authorities. Dr. Mauro Biffoni participates in the PhD by integrating skills in the field of pharmacology (SSD / BIO14) University of Naples Federico II Department of Public Health Prof. U. Malapelle (RTD-B SSD/MED50) The Cytopathology and Predictive Molecular Pathology unit that belongs to the Department of Public Health of the University of Naples Federico II consists of four functional areas divided in relation to the different phases of the "workflow" for the preparation and preparation of the cited sample - histology, the extraction of nucleic acids, the implementation of molecular biology methods for the analysis of genetic determinants functional to predictive molecular pathology and data analysis. The first functional area is used for the preparation of the sample for subsequent second level analyzes. This area is equipped with an area for preparing the preparations by means of microtome cutting, an automatic instrument for the staining of cyto / histological preparations, an automatic system for immunohistochemical investigations, a space for the manipulation of cyto / histological samples to be initiated for second level molecular biology investigations and for manual microdissection and subsequent isolation of nucleic acids, purification of nucleic acids by manual procedure. The area is also equipped with two specific centrifuges for the manipulation of blood samples and the isolation of free circulating DNA (cfDNA). The second functional area is used for the manipulation of pre-amplified samples. The area is equipped with a sterile laminar flow hood used for the preparation of mixes and for the preparation of libraries of samples processed by next generation automatic sequencing (NGS). The structure also has a nanofluidic system of massive and parallel hybridization with fluorescent probes through which to analyze specific gene rearrangements qualitatively and quantitatively (Nanostring
NEUROSCIENZE CLINICO-SPERIMENTALI E PSICHIATRIA;CLINICAL/EXPERIMENTAL NEUROSCIENCE AND PSYCHIATRY;16183;2021;Scuola di dottorato in Neuroscienze;DIPARTIMENTO DI NEUROSCIENZE UMANE;Cristina LIMATOLA (cristina.limatola@uniroma1.it);3;10;1;0;Giorno: 6/9/2021;;Giorno: 20/9/2021 Ora: 09:00 Aula: Aula B e C Indirizzo: Viale dell'Università 30, 00185 Roma;tatiana.bassi@u

Exam - Oral

Giorno: 24/9/2021 Ora: da definire Aula: da definire in seguito Indirizzo: da definire in seguito

Department
Dipartimento di medicina sperimentale
Coordinator

Marianna NUTI (marianna.nuti@uniroma1.it)

Staff

Coordinatore del Dottorato: Prof.Marianna Nuti; tel. +390649973029email: marianna.nuti@uniroma1.it, Dipartimento di Medicina Sperimentale, Viale Regina Elena, 324 00161 Roma. Segreteria del Dottorato di Network Oncology and Precision Medicine: Sig.Katia Monteverde, tel: +39 0649918209, email: katia.monteverde@uniroma1.it, Dipartimento di Medicina Sperimentale, piano terra, Viale Regina Elena, 324 00161 Roma.

© Sapienza Università di Roma - Piazzale Aldo Moro 5, 00185 Roma - (+39) 06 49911 - CF 80209930587 PI 02133771002