DAIbetes

DAIbetes - Federated virtual twins for privacy-preserving personalised outcome prediction of type 2 diabetes treatment

ID Call: HORIZON-HLTH-2023-TOOL-05 Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management

 

Sapienza's role in the project: Other beneficiary

Scientific supervisor for Sapienza: Cosimo Durante

Department: Translational and Precision Medicine

 

 

Project start date:  January 1, 2024

Project end date: December 31, 2029

 

 

 

 

Abstract:

Virtual twins may be used as prognostic tools in precision medicine for personalised disease management. However, their training is a data-hungry endeavour requiring big data to be integrated across diverse sources, which in turn is hampered by privacy legislation such as the General Data Protection Regulation. Privacy-enhancing computational techniques, like federated learning, have recently emerged and hold the promise of enabling the effective use of big data while safeguarding sensitive patient information. In dAIbetes, we build on this technology to develop a federated health data platform for the clinical application of the first internationally trained federated virtual twin models. Our primary medical objective is a personalised prediction of treatment outcomes in type 2 diabetes, which afflicts 1 in 10 adults worldwide and causes annual expenditures of ca. 893 billion EUR. While healthcare providers are becoming increasingly effective at targeting diabetes risk factors (e.g. diet or exercises), no guidelines as to the expected outcome for a given treatment for a specific patient exist. To address this urgent, yet unmet need, the federated dAIbetes technology will harmonise existing data of ca. 800,000 type 2 diabetes patients of 4 cohorts distributed across the globe, and learn prognostic virtual twin models. Those will be validated for their clinical relevance and applied in clinical practice through dedicated software. We aim to demonstrate that our personalised predictions have a prediction error that is at least 10% lower than that of population average-based models. This federated virtual twin technology will enable personalised disease management and act as a blueprint for other complex diseases. Our consortium combines expertise in artificial intelligence, software development, privacy protection, cyber security, and diabetes and its treatment. Ultimately, we aim to resolve the antagonism of privacy and big data in cross-national diabetes research.

Sapienza University of Rome will provide a large patients’ dataset, and will take care of making it machine-accessible, with the relevant mapping to international ontologies and standards. Computer scientists will be involved in the privacy-preserving training processes, providing the technology infrastructure and knowledge, while clinicians will contribute to defining research and clinical needs, also testing the new approaches and validating the final model and software for use in clinical practice. We will also be involved in all the activities of communication, dissemination and engagement.

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