Notizia
... rosa of sapienza university of rome and the center for life nano science of the italian institute of technology (clns - iit rome), ... innovation award, the national reference competition for startup projects from the italian research world. the multidisciplinary ... cells are inserted into an organic matrix suitable for 3d printing and, thanks to the bioprinting, a state of the art technique ... by offering a new method to study and test drugs". the prize for equal opportunities, received not only for the prevalence of female researchers within the team, but also for the development of technologies that can be dedicated specifically to the ... of skills and interests created within the
center for life nano science
(clns), center of sapienza university of rome and of ... and maria rosito (technologist), has been working for 6 years in the development and functional characterization of in vitro ...
Notizia
Data notizia: Thu, 08/08/2024 - 12:15
... been described in the last decade of research as crucial for modulating the expression of information contained in genes and the processes that determine the development ... the branching of neural extensions (neurites) responsible for the transmission and reception of nerve impulses was described.
the ... the list of possible targets and therapeutic approaches for the treatment of neurological diseases. the researchers, coordinated by ... regulates the expression levels of ncam1, a protein crucial for neuronal function and especially for regulating neurite branching. the researchers were able to dissect in ... describes a hitherto uncharacterised mechanism of action for non-coding rnas, contributes significantly to
expanding our knowledge of ... 2024
https://doi.org/10.1093/nar/gkae590
further information
irene bozzoni department of biology and biotechnology charles ...
Notizia
Data notizia: Fri, 23/02/2024 - 12:00
... in italy, including sapienza university of rome,
revealed for the first time the mechanism of survival and progression of this tumour
, paving the way for new therapeutic approaches. according to the researchers, this is due to ... but is often lost during the early stages of neoplastic transformation.
the mir-15a acts as a molecular brake that keeps the levels of the fra-2 protein, a transcription factor that is crucial for the tumour's response to stress, at a constant low level.
in the ... cascades to activate the transcription of genes crucial for their survival. among the target genes of fra-2 is the igf1-receptor, which is responsible for the proliferative stimulus. "the discovery of this mechanism", says gian ... understanding of the disease and provides a useful rationale for the design of therapies.
in our models, pancreatic cancer under nutrient ... dependent on the activation of the igf1 receptor and therefore extremely sensitive to its pharmacological inhibition, which becomes a ...
Notizia
Data notizia: Wed, 13/02/2019 - 13:00
... and biotechnology charles darwin at sapienza and the center for genetic regulation of barcelona, has discovered with theoretical models and ... journal
. rnas, in addition to having a fundamental role for the cells that produce proteins, can be responsible for an abnormal protein aggregation that becomes toxic to the brain, if not ... examined tra2a tends to aggregation, it does not perform a correct splicing process, causing the alteration of many rna that can ... of the disease and this could lead to
new approaches for the cure
." this work creates the foundation for innovative treatment methods. at the moment the team has a protein deposit to be tested for fxtas and would like to extend its work into other complex diseases,
... doi: 10.1016/j.celrep.2018.11.076.
further information
gian gaetano tartaglia department of biology and biotechnology ...
Notizia
Data notizia: Fri, 17/05/2024 - 12:00
... latest frontier in physics. dna lends itself to being used for this purpose
due to the complementarity of the four nitrogenous bases,
which makes it very versatile and suitable for joining into compounds. through a mechanism known as 'self-assembly', the molecules themselves, even in enormous numbers, form an organised structure as a consequence of specific and local interactions ... two alternative and different construction processes. the former are all similar to each other and are designed in such a way that they ... to their corresponding one, in a very specific position, to form a predefined design. the scientists' choice therefore lies in the middle:
not bricks that are all the same to have infinite ... different elements to create exactly and only the desired conformation.
the key to the solution was to translate this theoretical ... on the computer and then obtain in the laboratory a crystalline material that has never been assembled before, clearly demonstrating the ...
Notizia
Data notizia: Thu, 10/02/2022 - 17:45
is einstein's general relativity the correct theory for gravitational phenomena? can these phenomena be used to discover new ... sasso science institute (gssi), the international school for advanced studies (italian acronym sissa) and the university of nottingham, ... fields associated with gravity, particularly scalar fields, form the basis of theoretical models developed to explain various physical scenarios. they could, for instance,
provide clues to the accelerated expansion of the universe or ... are more relevant when space-time curvature is very large. for this reason,
the observation of gravitational waves
- which has ... to be observed with lisa and
represent a precious arena for studying the strong gravitational field regime
. the smallest body in an emri completes tens of thousands of orbital cycles before falling into the supermassive black hole, thus emitting long-lived signals ... the signal emitted by emris,
studying rigorously for the first time whether and how lisa can detect the existence of scalar ...
Notizia
Data notizia: Tue, 25/05/2021 - 15:45
... researchers from sapienza university, the national agency for new technologies, energy and sustainable economic development (enea), the ... statistically compatible are the data provided by satellites for the study of 'primordial fossil radiation' (a map of the residual light ... other cosmological parameters,
it serves to estimate, for example, the age of the universe (about 13.8 billion years),
the ... interpretive scenarios in which modified gravity models, for example, could be tested.
references:
on the hubble constant ...
2021 doi: 10.3847/1538-4357/abeb73
further information
giovanni montani department of physics ... from sapienza university of roma, the national agency for new technologies, energy and sustainable economic development (enea) and ... interpretive scenarios in which modified gravity models, for example, could be tested
cosmology: the 'hubble constant' is not ...
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Data notizia: Mon, 13/09/2021 - 11:45
... to their flexibility and power: from the transmission of information and energy, to radar, to the diagnostic and therapeutic medicine. ... , which hinder their propagation and cause them to be transformed into other forms of energy. a research group at sapienza university of rome, coordinated by the department of information engineering, electronics and telecommunications (diet), in ... with other italian universities,
has verified, for the first time, the physical phenomenon of deep penetration of ... using devices that
allow the waves to "travel" through, for example, soil or biological tissues
. the research, published in the ... with biological tissues but also the transmission of information in dissipative materials, material analysis and microscopy
. "this ... although the study verifies the effect of deep penetration for a specific value of frequency and conductivity (the structures involved ...
Notizia
Data notizia: Fri, 17/07/2020 - 11:30
... and have, in fact, not one, but two different molecular forms:
a form in which each molecule is locally surrounded by four other molecules arranged with a tetrahedral (ordered) geometry, forming strong bonds (the hydrogen bonds) with four neighbours, and one in ... differently from all other liquids existing in nature.
for example, as a solid it has a lower density than as a liquid (which explains ... and pablo debenedetti's team at princeton university (usa). for the first time, research has shown that
at very low temperatures the ... of water" is a real phase transition, just as it happens, for example, from a solid to a gaseous phase. in particular, researchers have ... demonstrated, with quite accurate models, a critical point for the liquid-liquid transition: the theoretical proof that was needed to ... needed to achieve these results, a real numerical tour-de-force that required an enormous amount of computing resources, both in rome and ...
Notizia
Data notizia: Mon, 20/06/2022 - 11:30
... the two sexes are well recognised in various diseases, for example, cardiovascular diseases, clinical trials have for years neglected this aspect also in terms of study design, involving predominantly male patients. for the first time,
a randomised, placebo-controlled trial was specifically ... type 5 inhibitors (pde5i), such as viagra and cialis. for this reason, the indication of pde5i turned to the andrological field, ... renal disease) and
menopausal women at risk for renal disease,
opening up interesting scenarios on the role of oestrogen ... that their possible use in women has been ignored. we, therefore, insisted on investigating other targets for these drugs. after demonstrating the efficacy of pde5i on cardiac ... women may respond differently to drugs and, therefore, should be adequately represented in clinical trials'. it is important to ...
Notizia
Data notizia: Wed, 05/01/2022 - 17:15
... molecular cell
journal and funded by the airc foundation for cancer research, represents a further advance in the elucidation of the ...
making this circuit an interesting candidate for new rna-based medical therapies. these results underline the importance of studying the interactions between non-coding rnas and ... https://doi.org/10.1016/j.molcel.2021.11.032
further information
irene bozzoni department of biology and biotechnology "charles ... in children. the study, funded by the airc foundation for cancer research and published in molecular cell journal, opens the way to new treatments for childhood malignancies
pediatric cancer treatments: new possibilities ...
Notizia
Data notizia: Thu, 23/05/2019 - 13:30
the determination of sex in mammals, and therefore in humans, is defined by the presence of sexual chromosomes: males carry a ... mary university of london and mitchell guttman of the california institute of technology, has analyzed the process of inactivation of the ... network is so great that xist and its partners proteins form a structure that resembles a corpuscle, conceptually similar to a drop of ... characteristics of the granules, we propose for the first time xist as a complex that, together with the proteins that bind to it, behaves as a
functional unit for inactivation
." the research results allow not only to deepen the ... means of phase separation and that a few xist molecules can form silencing gradients capable of spreading the silencing signal over large ... https://doi.org/10.1038/s41594-021-00697-0
further information
gian gaetano tartaglia department of biology and biotechnology ... with the european molecular biology laboratory, the centre for genomic regulation barcelona, queen mary university of london and the ...
Notizia
Data notizia: Tue, 22/03/2022 - 12:30
liposomes are the ideal tool for drug delivery in cancer therapies in the biomedical field. these ... side effects. however,
only a small number of liposomal formulations have been approved by regulatory agencies and have entered ... crown' and
are recognised by the immune system as a foreign body to be eliminated
. therefore, what the immune system is fighting is not the liposome itself but the ... 2022 https://doi.org/10.1021/acsnano.1c07687
further information
giulio caracciolo department of molecular medicine ... university of rome has developed a new type of nanoparticle for drug delivery and transport, which, thanks to a coating of human plasma ... can deceive the immune system and remain in the body for a long time. the results have been published in the journal acs nano
...
Notizia
Data notizia: Fri, 30/10/2020 - 11:45
... age, muscles tend to lose part of their mass, and therefore their strength
,
as well as their ability to repair and regenerate ... expression,
that series of events that translate the information contained in a gene and lead to the formation of a protein. the study showed that experimental drugs that activate ... study has only been experimented on animals, paves the way for
possible approaches to improve the health of elderly people debilitated ... https://doi.org/10.1038/s41556-020-00593-7
further information
antonio musaro department of anatomical histological medical legal ... rome and european and american laboratories, paves the way for new therapeutic possibilities also for people suffering from neuromuscular pathologies. the research has been ...
Notizia
Data notizia: Fri, 17/04/2020 - 12:00
... in amyotrophic lateral sclerosis), funded by arisla (call for projects 2019). the research outcomes, suggesting
nk cells as new ... https://doi.org/10.1038/s41467-020-15644-8
further information
cristina limatola department of physiology and pharmacology ... and collaborated in a new international study that proves, for the first time, the involvement of natural killer cells (nk) in the early ... journal, suggests a new possible therapeutic target for the development of specific therapies
natural killer cells of the immune ...
Notizia
Data notizia: Wed, 26/03/2025 - 09:00
sapienza is organising a series of events for lecturers and researchers interested in learning more about the ... msca programme, the european commission's main instrument for doctoral and post-doctoral training and the career development of ...
Notizia
Data notizia: Tue, 02/05/2023 - 12:00
... workshop "planning an msca-pf proposal @ sapienza: key steps for a successful application". the workshop, in english and blended mode, is for all researchers, internal and external to sapienza, interested in ...
Notizia
Data notizia: Thu, 03/03/2022 - 11:30
... aula magna will be hosting the meeting "grazia deledda, a forgotten nobel" for international women's day. the event will focus on the figure of grazia ... the only italian female writer to have won the nobel prize for literature.
event in italian: grazia deledda, a forgotten nobel ...
Pagina
... of professors, researchers, postgraduates and doctoral students, sapienza promotes internal funding tools, provided annually through ... most important calls include: sapienza research call. call for proposals for university research, including specific actions for "large, medium and small research projects", "h2020 projects", "research initiation projects". the call for medium and large equipment of common interest to the university aims at financing projects for the purchase of medium and large equipment for the development and strengthening of sapienza's high-quality research ... research in the field, in italy and abroad. call for conferences, seminars and workshops . sapienza publishes the call for ...
Notizia
Data notizia: Wed, 17/11/2021 - 13:30
sensorboa is an experimental prototype developed by the students of the innovative sensing nanoelectronic devices course
of the ... coordinated by fernanda irrera of the department of information engineering, electronics and telecommunications, aimed at monitoring ...
it can be easily used both in real time and offline by accessing a specific web page.
students of the innovative sensing nanoelectronic devices course of the ...
Notizia
Data notizia: Wed, 26/03/2025 - 09:00
... in collaboration with the american chemical society; students will have the opportunity to network with leading authors of acs ...
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Data notizia: Wed, 22/11/2023 - 15:15
... on the role of climate change in the sahara.
using the information contained in the whole genomes of 43 individuals, and applying new ... with other modern and ancient genomes in the literature.
for the first time, a strong genetic affinity between the fulani and ... findings, was
highlighted.
using an approach never before applied to the african continent, the joint analysis of modern and ancient ... are not yet well characterised", says flavia risi, a phd student in genetics and molecular biology at sapienza university of rome and ... and migrations between populations in the "green sahara", forming a kind of "pan-saharan" population,
which then became definitively ... populations, and the results of this study help to draw a line between the ancient saharan pastoralists and the modern fulani", says ... is still little studied on a genomic level. in addition to information on the peopling of the green sahara, the genome sequences produced during this study represent an essential tool for the scientific community as they allow us
to fill, at least in part, a ...
Notizia
Data notizia: Wed, 16/09/2020 - 16:00
... current
covid-19 emergency represents a daily test-bed
for the scientific world, both for the identification of a vaccine able to end the disease for good and for the development of therapies able to curb the strength of the virus. today, ... panorama of scientific contributions belonging to the line of research launched to overcome the pandemic. the paper, published on ... covid-19 progression.
on a sample of 70 patients positive for sars-cov-2, the researchers observed that oral bacteriotherapy
... of symptoms and reduction in the evolution towards severe forms of disease". although it needs to be further confirmed in broader ... of the study corroborate bacteriotherapy as a promising line of research on covid-19.
references:
challenges in the management ...
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... activities of professors, researchers and doctoral students. to this end, it promotes and financially supports several calls for proposals addressed to the scientific community that differ according to the priorities and objectives set. sapienza also offers information, training and technical assistance services for the identification of funding opportunities, for the presentation and management of projects financed within the framework ... by local, national and international authorities, as well as for participation, as an economic operator, in tenders issued by ministries, ...
sapienza research calls
regional and national calls for proposals
external opportunities and fundings
italian national ...
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the sua-rd (acronym for "scheda unica annuale della ricerca dipartimentale" - single annual report ... and provides them with useful data and markers. sua-rd information provides all interested parties (students, families, companies, public agencies, etc.) with updated information on department competences and research areas, contributing to improve ... research and civil society.
publication of guidelines for completion of the single annual report on third mission and social impact (sua-tm/is) for universities
on november 13, 2018, anvur published the guidelines for completing the single annual report on third mission and social ...