On September 15, 2022, Sapienza's Aula Magna hosted the Opening Ceremony of the 2022-23 Academic Year, the 720th since its foundation.

During the event, an honorary doctorate in Political Studies was awarded to Giuliano Amato, president of the Constitutional Court and former constitutional law professor at Sapienza University from 1975 to 1997. Musa Classica, Jazz and MuSa Choir performed GaudeaMuS.

After institutional greetings by the Mayor of Rome Roberto Gualtieri and the Minister for Universities and Research Cristina Messa,  Rector Antonella Polimeni delivered her opening speech entitled Dalla società della conoscenza alla società per la conoscenza. Polis universitaria e cittadini del sapere, del saper fare, del saper essere e del saper trasmettere.

Chiara Cataldi, student representative of Sapienza's School of Advanced Studies talked about La Scuola Superiore di Studi Avanzati Sapienza, un modello di inclusione, merito e formazione aperta, and Maria Romana Forte, manager of the Centro di ricerca e servizi per l'Innovazione tecnologica sostenibile Cersites (Latina) about Università, un sistema complesso. La sfida dell'innovazione.

Luca Micheletta, coordinator of the PhD in Political Studies, delivered his speech of praise for Giuliano Amato.

Giuliano Amato's lectio magistralis Le nostre fragili democrazie e il clima. Possiamo attrezzarle per farcela? was followed by the solemn inauguration of the new academic year.

MuSa closed the ceremony by performing Io la musica son and the toccata from Claudio Monteverdi's Orfeo.